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Following menthol administration, male rats self-administered more intravenous nicotine infusions and increased their motivation to obtain nicotine (151), and male mice self-administered electronic cigarette vapor containing menthol and nicotine at greater levels than nicotine vapor alone (61)

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doi: 10.1002/dmrr.2769 91 KumarSMukherjeeTKGuptasarmaP

Ethics declarations Ethics approval and consent to participate This simulation model-based research was approved by the Mass General Brigham Human Research Committee (Protocol #2019P001772)