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Description
In 2025, the semaglutide Rybelsus was the first oral GLP-1 to receive the indication

A site that is difficult to reach can increase the chance of shaky technique, short hold time, or uncertain placement

Why an Injection

Rather than forcing metabolic change through brute biochemical intervention, GLP-1 drugs supraphysiologically modulate endogenous signalling systems already evolved for energy regulation

Laparoscopic sleeve gastrectomy in children and adolescents with Prader-Willi syndrome: a matched-control study

doi: 10.1073/pnas.0806720106
