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METHODS Animals and smoking exposure Forty-eight male ApoE knockout mice aged 6 weeks were purchased from the Experimental Animal Center of Xian Jiaotong University

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20 In a retrospective chart review of 48 patients with chronic obstructive pulmonary disease (COPD), including 24 daily e-cigarette users and 24 matched traditional cigarette smokers, e-cigarette users showed decreased COPD exacerbations, improved patient-reported COPD health status, and a reversal in expiratory volume decline over 24 months of follow-up