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LITERATURE REVIEW 1) Cigarette smoking effects on the respiratory epithelium The epithelium coating the upper respiratory tract acts as a first line of defense against invasive agents (pollutants, allergens, microorganisms), and it can cause upper airway symptoms and diseases when in contact with these agents.5 Inhaled cigarette smoke, both passively as well as actively, has been associated with chronic irritation and discomfort on the eyes, nose and oropharynx.6 Since 1964, when a report was published about smoking by the U.S

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The manufacturing or production date of the cigarettes is displayed in the packaging to let you know that the tobacco products can last for another year or two, granted that you store them optimally

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Studies on human bronchial epithelial cells, human urothelial cells, and lung and bladder tissues recovered from postmortem mice exposed to e-vapor, showed high tumorigenic transformation due to the nicotine metabolites N -nitrosonornicotine and nicotine-derived nitrosamine ketone [85]

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