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CHANTIX was evaluated in a randomized, double-blind, active and placebo-controlled trial that included subjects without a history of psychiatric disorder (non-psychiatric cohort, N=3912) and with a history of psychiatric disorder (psychiatric cohort, N=4003)

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Successive studies have found that recombinant human tumour necrosis factors receptor: Fc fusion protein (rhTNFR: Fc) may interfere with tumour necrosis factor (TNF-) and reduce alveolar septal apoptosis in CS-induced rats [35]