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It produced a good amount of smoke and I was rewarded with that beautiful, old-world pipey aroma that I find so appealing with a good Dutch blend

This is your first and best clue about the kind of effects you can expect

Formulations of NRT products currently available in the United States include nicotine gum, lozenge, transdermal patch, nasal spray, and oral inhaler (Table 3)

J Biochem (tokyo) 96:19151923

We can induce changes, but it doesnt mean something else wont also change in an undesirable direction, Lewis said

This result is consistent with the idea that nicotine is an anti-inflammation molecule in both the nervous system and the immune system (Zhang et al., 2022)