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Some individuals have stronger brain responses to these nicotine-related cues than to non-drug-related rewards

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Evidence of altered brain responses to nicotine in an animal model of attention deficit/hyperactivity disorder

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doi: 10.1136/tc.2008.024778

[161] find that the activation of IB is critical in the phospho-acetylation of histone H3 on the pro-inflammatory gene promoters in response to CS stimuli and the histone H3 phospho-acetylation is critical for the activation of NF - B -directed gene expression