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First, the bias covariates used, although carefully extracted and evaluated, were based on observable study characteristics and thus may not fully capture unobserved characteristics such as study quality or context, which might be major sources of bias

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"The 50th anniversary of the Surgeon General report should be a catalyst to say, 'We can't wait another 50 years to end death and disease caused by smoking,' " says Matthew Myers, president of the Campaign for Tobacco-Free Kids, an advocacy group