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miR-214-3p can not only inhibit the expression of IFN- and intestinal inflammation (Li et al., 2017), but also activate the NF-B pathway and promote intestinal inflammation (Liu et al., 2019)

Moreover, Qi et al

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Polyethylene glycol-like brush polymer conjugate of a protein drug does not induce an antipolymer immune response and has enhanced pharmacokinetics than its polyethylene glycol counterpart

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This integrated MD simulation optimization strategy reveals structure-activity relationships at the atomic scale, significantly improving the success rate of drug design, which has therefore become an important paradigm in innovative drug development (Wade and Salo-Ahen, 2019)