Prescribing Information
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Description
Anti-apoptotic effects of GLP-1RAs In both diabetic and non-diabetic rodent models of cerebral ischemia, exenatide, lixisenatide, semaglutide, and liraglutide increased the expression of the anti-apoptotic factor B-cell lymphoma 2 (Bcl-2) and decreased the expression of the pro-apoptotic factor Bcl-2-associated X protein (Bax), consequently leading to a reduced Bax/Bcl-2 ratio and reduced apoptosis, possibly through ROS reduction and activation of the PI3K/Akt and MAPK pathways [73, 86, 87, 92, 93]
Any decision to start GLP-1 medications should be based on a comprehensive evaluation of the individual's overall health status, personal medical history, and treatment goals
2024;149(12):e450e468
[DOI] [PubMed] [Google Scholar] 12.Kieffer TJ, Habener JF
Semaglutide: In clinical trials, patients lost an average of 15% of their body weight over 68 weeks
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