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In vivo studies indicate that roflumilast mitigated cigarette smoke-induced airspace enlargement and alleviated bleomycin-induced lung fibrotic and vascular remodeling in mice [161, 162]

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7 Role of Air Pollution on CV Health Air pollution is formed by the combination of particulate matter (PM), mainly derived from the combustion of carbonaceous particles, and several gaseous pollutants, such as nitrogen dioxide, nitric oxide, sulphur dioxide, carbon monoxide, volatile organic compounds and ozone

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There is no framework available in which theres not harm somehow