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Risk for Impaired Gas Exchange Rationale: Smoking reduces the surface area available for gas exchange in the lungs, leading to hypoxemia and hypercapnia

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Appendectomy, low dietary vitamin D, oral contraceptives, postmenopausal hormone, NSAIDs, antibiotics, depression and psychological stress, high dietary fat, and high dietary protein are a few more environmental factors that contribute to CD and immune cells also penetrate the gut of the CD patients [58]