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IMs are located between alveolar epithelial cells, and unlike AMs, are negative for CD169 (Siglec-1 or sialoadhesin), a cell adhesion molecule shown to discriminate phenotype between AMs (CD206+CD169+) and IMs (CD206+CD169)

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They gained popularity due to their perceived reduced harm compared to traditional cigarettes

Dawkins L, Turner J, Roberts A, Soar K

I switched to iqos due to pressure from kids n wife, I smoked a pack of regular smokes and a pack of heat sticks and after about a month im only using iqos, Ive gone through and going through a bunch of withdrawl Symptoms linked to smoking which I can only assume is actually from the tar in smokes

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