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In the layer mask paint with 100% black on the edges (in order to reveal the saturation effect only on the hand and the face)

Maternal smoking during pregnancy was found to significantly reduce the methylation of the gene PRDM8 (PR domain contain 8), which is a gene thats tightly regulated in a spatiotemporal manner during neural development and is important for regulating the morphological transition in neocortical development [4953]
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