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discovered that 3-phenylquinazolinones are potent FSP1 inhibitors, inducing the subcellular relocalization of FSP1 from the membrane but not inhibiting FSP1 enzyme activity to accelerate ferroptosis via a phase separation mechanism [49]

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doi: 10.1016/j.molcel.2012.09.025

In aged erythrocytes, on the other hand, a high intracellular Ca 2+ level likewise plays a particular role in the initiation of different apoptotic pathways

a more detailed historical perspective has been reviewed elsewhere

Philp, D., Badamchian, M., Scheremeta, B., et al