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They hoped to pin down exactly what may drive the high cancer rates in the breed and what can be done to minimize the risks to Scotties, other dogs, and even humans
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46,47 In non-joint tissues, cigarette smoke has been shown to affect macrophage recruitment, phenotype, phagocytosis, efferocytosis, reactive oxygen species handling, and cytokine signaling, which suggests broad macrophage reprogramming rather than one simple polarization change
10.1371/journal.pone.0182998 8 AmereG
