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Literature studies indicate that neuroadaptations within prefrontal cortical-hippocampal-striatal circuits, interconnected via glutamatergic signaling, are dysfunctional in SUD and may represent common mechanisms triggered in the case of chronic use of drugs of abuse and relapse [2]

pmid:14248595 Edwards J, Bartlett JM (2005) The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer

12,57 Growing numbers of studies have proved that imbalanced metabolites are correlated with diseases

The most recent clinical guidelines for intensive care recommend a protein intake of 1.22.0 g/kg/day (30), which is associated with lower mortality rates (35)

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Metabolomics analysis is one of the most applied omics analysis that facilitates understanding of the modulation of small molecules following exposure