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Because CYP2A6 is involved in the metabolism of nicotine, the presence of these chemicals could decrease smokers metabolism of nicotine and maintain higher blood levels (thus increasing smokers exposure to nicotine by slowing degradation of nicotine in the bloodstream)

Prostaglandin E2 (PGE 2) Prostaglandins enhance mucosal blood flow, mucosal secretion, and bicarbonate synthesis while decreasing stomach acid output

Bibcode:2007WeedT..21..332W

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Conflicts of Interest There are no conflicts of interest to declare
