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This can lead to oxidative damage to cells and tissues, including the brain vascular system and the BBB, over a period of sustained exposure to TS (e.g., chronic smokers) and facilitate the pathogenesis and progression of neurological disorders [4042]

They contain substances usually found in peppermint and spearmint plants and cause a cooling sensation while smoking

Nicotine on its own isn't great, but it's not what gives you lung cancer

By dividing areas into zones, local jurisdictions can control the types of businesses allowed to operate in certain zones

Pezzulo et al., 2011

Upon release, X's received generally favorable reviews from critics