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In study limitations, the researchers noted that the survey only asked vapers what device they mainly used, meaning that the proportion of vapers using disposables in some form would likely be higher

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[14] as noted above did not find EC use to be significantly associated with prevalence of functionally important respiratory symptoms (as noted in the section above), they did find exclusive EC use to be associated with worsening of functionally important respiratory symptoms in some analyses, though it depended on the exact cutoff used to denote functionally-important (i.e., 2 vs 3 on a 9-point scale) [14]

doi:10.1186/s12995-015-0047-8 Gerber A, Bigelow A, Schulze M, Groneberg DA (2015b) Brand cigarillosa cheap and less harmful alternative to cigarettes

What is the role of P450 enzymes expressed in the brain that metabolize THC and CBD 318