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2) the graphic components (color, imagery, descriptors) that are used on cigarette packaging

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Alarmingly, an additional 1.3 million deaths involve non-smokers, including infants and children, who are particularly vulnerable to second-hand smoke exposure ( Epidemiological evidence has firmly established the causal link between cigarette smoking and a wide spectrum of diseases, with lung cancer being the most prominent

However, the magnitude of these methylation changes was relatively small (below 1%), and the biological relevance needs to be further explored