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These effects are usually mild and decrease as your body adjusts to nicotine pouches

Through the secretion of COX-2, prostaglandin E2, VEGF, and ERK, as well as the activation of ERK and a COX-2-dependent rise in VEGF and VEGF receptor, nicotine promotes the development and relocation of gastric cancer cells

Journal of Hydrology 519, Part D, 34663474, (2014)