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Their main combustible brands are Newport, Natural American Spirit, Camel, Pall Mall, and Lucky Strike

In just the first quarter of this year, Philip Morris said, it sold 131.6 million cans of Zyn, up 80% from the same time last year

And those determined to do so have ready access to 19-year-old friends to buy tobacco for them

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34,37 The requirement for local metabolic activation of NNK in the mouse lung has been elegantly demonstrated by experiments using mice in which cytochrome P450-reductase, the requisite co-factor for cytochrome P450-catalyzed metabolic activation of NNK, has been knocked out in the lung, 38 and a polymorphism in Cyp 2A5 decreased NNK-induced DNA adduct formation and lung tumorigenesis, as seen in parallel epidemiologic studies of lung cancer

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