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The P values were corrected for multiple testing using the spatial BH method implemented in Milo (adjusting for the number of neighborhoods)

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blood, 2.17 vs 1.89, respectively)

Potential mechanisms include excess alkali intake with a low GFR (acute or chronic failure), volume depletion/chloride deficiency , hypokalemia (intracellular acidosis fools the kidney into retaining bicarbonate), and increased mineralocorticoid activity (due to volume depletion, primary hyperaldosteronism, Cushings syndrome) Topf, Fluid Electrolyte and Acid Base Companion , 1999

Studies suggest that it can accelerate healing in tendon injuries, ligament strains, and muscle damage