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The Italian Society of Tobaccology (Societ Italiana di TabaccologiaSITAB) guidelines suggest the following combination therapies: long-term use of nicotine patches (more than 14 weeks) plus a short-term NRT product (gum or spray) or nicotine patches plus bupropion SR

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Chandirasekar, one of the authors of the study said: "The result of our study revealed that tobacco users displayed varied levels of elevated chromosomal damage and the extent of genetic damage was dependent on the duration of the tobacco use"

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After each pill the volunteers were asked to report their symptoms, such as relaxation, changes in energy levels, lightheadedness, or jitters