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In the recent past, there has been emerging interest among researchers in smoking as a risk factor for developing schizophrenia spectrum disorder the smoking causes schizophrenia hypothesis (Box 2)

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This proposal allows for the start of an important conversation about how we meaningfully tackle one of the deadliest consumer products in history and profoundly change the landscape of tobacco product use in the United States. The agency is committed to providing multiple opportunities for public engagement on the proposal

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