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Instrumentation LC-MS/MS analyses were carried out with a Thermo Accela UPLC pump and Pal Autosampler interfaced to a Thermo Vantage triple-stage quadrupole mass spectrometer, or with a Thermo/Dionex UltiMate 3000 RS Pump UPLC+ Focused UPLC and CTC/Dionex UltiMate 3000 XRS Open Autosampler interfaced to a Thermo Quantiva triple-stage quadruple mass spectrometer

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The PMTA pathway allows e-cigarette manufacturers to advertise if they can demonstrate that the marketing of the new tobacco product would be appropriate for the protection of the public health. The FDA determined that the benefits of e-cigarettes as smoking cessation tools outweigh the potential risk to young people because products aerosols are significantly less toxic than combusted cigarettes based on available data comparisons and results of nonclinical studies. In an attempt to discourage teen vaping, the FDA is denying e-cigarette companies the right to sell flavored e-cigarettes except for menthol

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