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Interestingly, tobacco smoke condensate increased the relative protein expression of DNA repair proteins KU70/KU80 (Fig

The relative protein expression of p-4EBP1 was significantly elevated in endothelial cells treated with tobacco smoke condensate combined with colchicine compared to control and endothelial cells treated with smoke condensate (Fig

Genome-derived cytosolic DNA mediates type I interferon-dependent rejection of B cell lymphoma cells

Proliferating cell nuclear antigen ( PCNA ), also a p53 transcriptional target, is a major coordinator of faithful and processive replication

SP141 and MA242 (MDM2 inhibitors) are the potential drugs for treating HCC, because their effectiveness had been confirmed in breast cancer models and pancreatic tumor mice 153,154

To understand the underlying mechanism, we investigated the impact of colchicine on the activation of NF-B, MAPKs, and mTOR pathways in smoke-condensate-treated endothelial cells