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Time Frame Nicotine reaches the brain in less than ten seconds upon first inhalation from cigarette smoke and the central nervous system in less than five minutes

Barthel L et al

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16 Feb 2015 E-cigs: toxic threat to dogs Both tobacco and nicotine replacement therapies are a source of acute poisoning in humans and animals

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The estimated difference between log-OR of the current versus never smokers and the former smokers versus never smokers was 0.10, 95% CrI 0.27 to 0.51 (OR 1.11, 95% CI 0.761.67), indicating that current smokers are slightly more likely to develop SLE than the former smokers, with statistical significance