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Availability of data and material The manuscript has data included as supplementary material

While flavored cartridgesespecially sweet oneshave been found to contain chemicals of questionable safety, theyre not necessarily the culprit behind these illnesses

This leads to a cycle of dependence where the user needs more of the drug to achieve the same effects

Interestingly, this occurred in a population of smokers who were not interested in quitting in the near future

Hoffman A

Obviously, the impressive increase in 2010 of more than 30% of a cigarette packs price definitely helped this change (with also 65% of taxes, adding 200 billion Yens / ~1.2 billions dollars each year in the States coffers)