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Patients should also be aware that muscle loss during rapid weight reduction is a documented concern with potent weight-loss agents

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Other possible effects include headaches, fatigue, and changes in blood sugar levels

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HIF-1 protects nucleus pulposus cells from oxidative stress-induced mitochondrial impairment through PDK-1

In this regard, the concept of treatable traits was defined to identify distinct clinical phenotypes and individualize treatments to achieve the best clinical outcomes in patients with bronchiectasis.16 Several studies have analyzed different systemic and local biomarkers, but only a few of them have demonstrated strong potential (Table 1).16 The vicious cycle hypothesis of bronchiectasis