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Against that backdrop we have analyzed six rulings in the second half of 2025 and described our analysis below

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Adjustable Airflow Slider From a tight, cigarette-style draw to a broad, direct-lung inhale

Overall, AEs were infrequently reported in this study, with six AEs reported by five (21%) subjects after study product randomisation

In particular, further investigation is needed to determine if reliance on pack-years is appropriate to guide healthcare policy or for enrollment in clinical trials of COPD, or for other uses, all of which typically rely on a minimum of a 10 pack-year history