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NNN, NNK, and NAT NNN and NNK are known carcinogens and NAT might be one

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Literature reveals hepatic lipid peroxidation-induced damage to the DNA causing mutation which might later lead to hepatocellular carcinoma in SLT users.[2,9] Higher serum SGPT, SGOT, alkaline phosphatase, and direct and indirect bilirubin levels were observed in cases when compared to controls in the present study and were statistically significant

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Finally, the square root of the T 2 statistic provided a sample estimate of the standard deviation of underlying effects of 0.009 around the mean effect 0.002