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A modest, yet significant increase in the release of matrix metalloproteinase-2 (MMP-2) was also observed in cultures treated with either 3R4F or NF smoke extracts, but not ultralow nicotine (Figure 6C)

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The publication of the Royal College of Physicians report, Smoking and Health in 1962 was a key moment

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While there is no pervasive burning tobacco smoke and smell, and the surrounding environment is more pleasant for non-participating bystanders, an average vape device contains the nicotine equivalent of 20 cigarettes