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Once in the body, it can lead to various short- and long-term health concerns

Approximately 80% of TP53 mutations are missense mutations occurring within the central sequence-specific DNA binding domain, which is clustered around a few hotspot amino acid residues

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In addition, Li-Fraumeni patients with certain hotspot p53 mutations, such as R248Q, show earlier onset of malignant disease compared with patients that harbour mutations that cause a loss of p53 protein [96]

It has been known for a long time that people who undergo chemotherapy to treat their cancer have a poor survival rate if they continue to smoke during the treatment

[DOI] [PubMed] [Google Scholar] 64.Dawkins L, Turner J, Hasna S, Soar K