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[139] Since e-liquid production is not rigorously regulated, some e-liquids can have amounts of impurities higher compared to limits for pharmaceutical-grade nicotine products

Moreover, smoking-related diseases, such as lung cancer, cardiovascular diseases, and respiratory disorders, have profound implications for healthcare systems worldwide

By February 2008, Ploom raised $900,000 in venture funding, putting its valuation at roughly $3 million, according to PitchBook

Although nicotine supplements are not commonly recommended

doi:10.1159/000342894 22