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According to the World Health Organization (WHO), alcohol and drug use accounted for 3.2 million deaths globally in 2019, with 2.6 million due to alcohol and 0.6 million to psychoactive substances [3]

Common side effects reported in clinical literature include: Nausea (often most pronounced during dose escalation) Vomiting Diarrhea or constipation Injection site reactions (for injectable forms) Headache Fatigue More serious considerations (discuss with your provider): GLP-1 medications carry boxed warnings regarding thyroid C-cell tumors

Severe gastroparesis and planned procedures Both Wegovy and Zepbound are not recommended in patients with severe gastroparesis

The most effective treatment involved a weekly dose of 2.4 mg semaglutide for 68 weeks

A Phase 2 trial of liraglutide told a related story, with no clear motor benefit but possible gains in non-motor symptoms and quality of life

There is no single GLP-1 with the fewest side effects for every patient