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The failure to articulate a clear methodology for APPH, grounded in market and behavioral realities, is part of a wider, long-standing problem: FDA has never set out, in detail or even in principle, how it believes the benefit-cost assessment implicit in APPH should be made, and this guidance does not address this deficit at all

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The guidelines state that no amount of alcohol is safe and that people should drink no more than two standard drinks per week to minimize their risk of cancer and other chronic diseases

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