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2 Importantly, the number of smokers in Africa is increasing, largely driven by the growing population

A better understanding of the mechanisms and various diverse signaling pathways responsible for nicotine plus HFD-induced NAFLD may also unveil novel pharmacological targets to treat fatty liver disease and adverse metabolic sequelae

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These items were partly selected to cover each of the main components of dependence (consumption, drive, craving, withdrawal, difficulty quitting) and adapted to use a scoring scheme reflective of evidence that dependence can exist at low levels of consumption, 12 and to measure aspects of dependence (e.g., cravings and withdrawal symptoms) that have been recommended as being of most practical use in assessing smokers