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In another human clinical trial involving 20 chronic smokers and 20 age-, sex-, and BMI-matched healthy subjects, cigarette smoking was shown to acutely worsen glucose tolerance in both healthy non-smokers and habitual tobacco smokers after smoking as few as 3 cigarettes (Frati et al., 1996)

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Even when tobacco was currency, that was only for small purchases

For those who smoke, this results in more rapid metabolism of drugs metabolized by cytochrome P450, which can lead to a clinically significant reduction in drug level and pharmacological effect in the body for some drugs

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However, they still contain nicotine, which is addictive and can have negative health effects