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E-cigs are devices that vaporize an addictive nicotine-laced liquid solution into an aerosol mist that simulates the act of tobacco smoking

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Battista Vai, 2012, PDF available)

Family aggregation related to lung cancer is likely multifactorial, including exposure to secondhand smoke, major genetic factors (e.g., chromosome 6p locus, CYP1A1 gene), other genes that modify risk of lung cancer, and genes that may enhance nicotine addiction or modify nicotine metabolism (DAmico, 2008

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