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proposed 49 , genetic instability (alterations/mutations) combined with chronic inflammation has greater ability to induce HCC initiation

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Like other miRNAs, miR34c can inhibit the transcription or initiate the degradation of target gene mRNAs by binding to the 3UTR (89)

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[11] demonstrated that pre-treatment of mice grafted with human skin samples with sunscreen before UVR exposure promoted the reduction of UVR-induced mutp53 [11]

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Gastroenterology 147 , 893902

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