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The paper states that, while the tobacco industry claims a 90-95% reduction in harmful and potentially harmful substances and toxicity for heated tobacco products, this is not the full picture

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Occasional smokers were excluded from the study

Smoking-driven gut microbiota destabilization exacerbates Crohns pathogenesis and activates colorectal oncogenic cascades Recent findings have highlighted that cigarette smoking disrupts gut microbial ecosystems, weakens intestinal barrier integrity, and triggers dysbiosis-driven inflammation