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Toxicants present in CS and e-vapor increase secretion of ROS that can further induce cell stress responses, such as proinflammatory pathways, unfolded protein response pathways, and alterations in cell differentiation, including goblet cell hyperplasia [71]

With the global rise in noncombustible nicotine or tobacco products (NNTPs), including electronic cigarettes and heated tobacco, an increasing proportion of former cigarette smokers discontinue use of combustible products yet continue nicotine exposure, in hopes of lowering health risks