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It has been observed that combining NRT strategies increases quit rates by 25% compared to NRT monotherapy, according to a 2022 article by Gaddey et al., published in the journal American Family Physician , titled Smoking Cessation Interventions . Varenicline delivered over a 4-week period has been found to be more effective at producing abstinence than bupropion and placebo, according to a 2024 article by Onwuzo et al., published in the journal Cureus , titled A Review of Smoking Cessation Interventions: Efficacy, Strategies for Implementation, and Future Directions . The abstinence rate for patients on Varenicline was 44% while those for bupropion and placebo were 29.5% and 17.7%, respectively