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However, the sample was also mostly female and more highly educated than the general population of Australian smokers and use of larger pack sizes is greater among males and the low-SES population [27], who also smoke more cigarettes per day on average [28]

Then these results could reflect the onset of leaf senescence after S2 and the accumulation of alkaloids during leaf early senescence

Global Tobacco Market Share by Distribution Channel (2023 & 2032) 14

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"Less serious" effects are those that are not expected to cause significant dysfunction or death, or those whose significance to the organism is not entirely clear