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Existing literature on the relationship between smoking and specific health outcomes is prolific, including meta-analyses, cohort studies and casecontrol studies analyzing the risk of outcomes such as lung cancer 5,6,7 , chronic obstructive pulmonary disease (COPD) 8,9,10 and ischemic heart disease 11,12,13,14 due to smoking

1 2 "Trends in market share of leading cigarette brands in the USA: national survey on drug use and health 20022013"

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who are 16 years or older and are natural persons