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The study has several limitations

The present study, as part of the Global Burden of Diseases, Risk Factors, and Injuries Study (GBD) 2020, re-estimated the continuous doseresponse relationships (the mean risk functions and associated uncertainty estimates) between current smoking and 36 health outcomes (Supplementary Table 1) by identifying input studies using a systematic review approach and employing a meta-analytic method 28

Quitting oral nicotine pouches like Zyn can be challenging, and the high levels of nicotine in these products can lead to nicotine addiction

MAN is of the view that the industry should be allowed what is called trade communication

doi: 10.1177/2045125320912125 17 CharlierP.CoppensY.MalaurieJ.BrunL.KepangaM.Hoang-OpermannV.et al

If cigarette smokers use the nicotine in pouches as a complete substitute for the nicotine in cigarettes to stop smoking, this would greatly reduce the risks to their health from smoking