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Bariatric surgery--which seeks to reduce the size of the stomach or bypass part of the GI tract--was conceived in the 1960s when surgeons observed that gastric cancer patients who had part of the stomach removed (subtotal gastrectomy) went on to lose weight

doi: 10.1111/bph.12490 55 SamsonSLSathyanarayanaPJogiMGonzalezEVGutierrezAKrishnamurthyRet al

Cost Analysis: Body Contouring After GLP-1 Weight Loss Understanding the financial investment required for body contouring helps patients plan appropriately and avoid unexpected expenses

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We previously showed that G protein-coupled receptor 17 (GPR17) is expressed in intestinal enteroendocrine cells (EECs) and modulates nutrient-induced GLP-1 secretion

This is consistent with research suggesting that these drugs broadly reduce neuroinflammation, which may also be a mechanism through which they improve anxiety and depression and reduce suicidality
