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J Clin Oncol 17:20862091 Sioris T, Husgafvel-Pursiainen K, Karjalainen A et al (2000) Survival in operable non-small-cell lung cancer: role of p53 mutations, tobacco smoking and asbestos exposure

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In a study conducted in a double-blind, placebo-controlled, sequential, multiple assignment randomized trial (SMART), patients who didnt respond initially to monotherapy like varenicline or combination therapy with CNRT were later shown to achieve abstinence via increasing the dosage of varenicline or patients who were already on CNRT to either increase the dose or to switch with varenicline ( 106 )